Coversyl (Perindopril)

Coversyl is used for treating high blood pressure. It may also be used to treat other conditions as determined by your doctor.

Use Coversyl as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• You may take Coversyl on an empty stomach or with food.
• Take Coversyl regularly to receive the most benefit from it. Taking Coversyl at the same times(s) each day will help you to remember to take it. Continue taking Coversyl even if you feel well.

Coversyl is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking ACE, an enzyme involved in narrowing blood vessels and causing sodium and fluid retention by the kidneys. This causes blood vessels to relax, allowing blood to flow more freely and at a lower pressure, and increasing the heart's ability to pump blood in some types of heart failure.

If you miss a dose of Coversyl and you are using it regularly, use it as soon as possible. Do not use 2 doses at once.

Store at the room temperature away from moisture and sunlight. Keep out of reach of children.

Do NOT use Coversyl if:

• you are allergic to any ingredient in Coversyl
• you are in the second or third trimester of pregnancy
• you have a history of giant hives or skin inflammation caused by ACE inhibitors
• you are taking or have taken dextran sulfate within the past 3 days

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of giant hives or skin inflammation, or hardening of the skin or organs
• if you have bone marrow depression, blood vessel problems in the brain (including stroke), or severe immune system disease
• if you are undergoing dialysis
• if you have high blood potassium, low blood sodium, or are on a sodium-restricted diet
• if you have ischemic heart disease, liver or kidney problems (including transplant), or lupus, or you are dehydrated

• Indomethacin, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or salicylates (eg, aspirin) because the effectiveness of Coversyl may be decreased
• Clozapine, cyclosporine, dextran sulfate, HMG-CoA reductase inhibitors (eg, simvastatin), indomethacin, mannitol, NSAIDs (eg, ibuprofen), pergolide, phenothiazines (eg, chlorpromazine), potassium, potassium-sparing diuretics (eg, triamterene), thiazide-type diuretics (eg, hydrochlorothiazide), or trimethoprim because the actions and side effects of Coversyl and these medicines may be increased
• Iron, lithium, sulfonylureas (eg, glyburide), or thiopurines (eg, azathioprine) because the actions and side effects of these medicines may be increased