Lotrel

Lotrel is used for treating high blood pressure.

Use Lotrel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Lotrel by mouth with or without food.

Grapefruit and grapefruit juice may increase the risk of side effects from Lotrel. Talk with you doctor before including grapefruit or grapefruit juice in your diet.

Do not take more than prescribed unless advised to do so by your doctor.

If you miss a dose of Lotrel , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lotrel.

Lotrel is a combination of 2 blood pressure medicines, an angiotensin-converting enzyme (ACE) inhibitor and a calcium channel blocker. It works by helping your blood vessels relax (dilate) and lower blood pressure.

If you miss a dose of Lotrel and you are using it regularly, use it as soon as possible. Do not use 2 doses at once.

Store at the room temperature away from moisture and sunlight. Keep out of reach of children.

Do NOT use Lotrel if:

• you are allergic to any ingredient in Lotrel or similar medicines (eg, any other ACE inhibitor)
• you are using iron dextran by injection
• you are in your second or third trimester of pregnancy

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement, especially extra potassium or a salt substitute
• if you have allergies to medicines, foods, or other substances
• if you have or ever had heart failure, any heart disease, aortic stenosis (an abnormal narrowing of the opening of the aortic valve in the heart), liver or kidney problems, a kidney transplant, or diabetes
• if you have systemic lupus erythematosus (SLE or lupus), hardening of skin disease (scleroderma), bone marrow suppression, low blood counts, low blood pressure, low blood sodium, high blood potassium, or narrowing or hardening of the arteries of the brain, or if you are dehydrated
• if you are scheduled to have surgery or are to receive anesthesia or kidney dialysis

• Dextran or sildenafil because the risk of serious side effects, including low blood pressure or severe allergic reactions, may be increased
• Potassium-sparing diuretics (eg, amiloride) or potassium supplements because the risk of side effects, including high potassium levels resulting in possible irregular heartbeat and stopping of the heart, may be increased
• Lithium, sulfonylureas (eg, glipizide), thiazide diuretics (eg, hydrochlorothiazide), thiopurines (eg, azathioprine), or vasopressin receptor antagonists (eg, conivaptan) because they may increase the risk of Lotrel 's side effects
• Insulin or oral diabetes medicine (eg, glyburide) because the risk of side effects, including low blood sugar levels (eg, hunger, shakiness or weakness, dizziness, headache, sweating), may be increased by Lotrel